Izzie patient, Denny Duquette, wants two things: 1. Addison detests Derek's trailer, Derek visits Meredith's mom, George treats a young teen hermaphrodite frustrated by her pre-pubescence. Other news includes patients doing uncanny things and relationship havoc being wrecked between the doctors, as per usual. Meredith and Cristina lie to each other and themselves about their relationships with McDreamy and Burke, respectively.
George is given a hard task to expel a discharged and defiant woman from the hospital. Alex learns his fate after re-taking his medical exams. At the same time Izzie is trying to stop Alex from making stupid decisions when a patient that doesn't speak English is lied to by her coach.
George, Cristina, and Alex compete in a hot dog eating competition. All the nurses at Seattle Grace Hospital go on strike, leaving the doctors to fend for themselves.
George refuses to cross the picket line and finally joins the nurses on their strike while Alex, Cristina, Izzie and Meredith meets Bailey's stand-in: Dr.
Cindy Aaron, the complete opposite of Miranda Bailey. Izzie agrees to work on a difficult pregnancy case with Addison, while Cristina and Alex are in the pit attending to a young married woman with a real bad case of rash. Meredith happens on an old woman that she needs to intubate and then learns she was DNR. An explosive case arrives at the O. Burke to declare a "Code Black" for the hospital. Bailey worries where her husband is as she is in labor. Also Izzie and Alex may be creating some heat.
Derek is still operating when he finds out about Meredith's current situation. Meredith is freaking out about her situation. Webber and Bailey are dealing with medical health issues. Cristina and Izzie have their own issues to deal with because of Meredith's situation.
Addison freaks out when George tries to find a solution to Bailey's impromtu postponement. Overall, Seattle Grace Hospital is still under code black and the situation is getting worse. Derek and Addison's relationship is rocked to the core when a former friend comes to Seattle Grace and his presence promises to shake things up for a few members of the staff.
Burke and Cristina's relationship is affected when one of her secrets is outted. Alex and Izzie are having similar reactions to their closet scenes during the Code Black crisis. On top of this a cocky doctor shows up to piss Derek off in all kinds of ways. A patient is suffering from constant orgasms and her condition sparks interesting conversations among the staff.
George is trying to figure out how to get Meredith to see him as more than just a housemate. Another patient, that Derek is treating, is dealing with a rare disorder and needs his parents support and understanding. Burke has a patient who inspires him to talk to Meredith and Cristina about doing what they say they will.
Meanwhile, Meredith learns more about her family in fact maybe more than she may have wanted to know through her parents. Meredith and George are experiencing morning-after tension at home and at work and it has the rest of the doctors wondering what's up.
Derek and Addison are experiencing their own version of morning-after tension as a result of Mark's visit to Seattle. Bailey, returning the favor that was done for her during the Code Black situation, must treat Addison for a specific feminine problem.
Izzie and Alex are making headway in their relationship until Denny Duquette comes back. Soon Alex is not-so-oddly jealous of the attention Izzie is showing to Denny. Someone finds comfort in confiding in a patient who is going through an ordeal of his own.
The doctors are up to their necks in their usual levels of drama. Meredith is dealing with the backlash of sleeping with George, George and Burke are bonding in ways that bother and creep out Cristina, Cristina gets stuck on diaper duty, Bailey gets involved in a case even though she's still supposed to be on maternity leave, Addison and Derek have a talk, and Izzie is still flaking on Alex for Denny Duquette, the heart patient who didn't get a heart.
In the patients-of-the-week department we've got a very pregnant woman, a hockey player who desires medically unnessasary amputation, and a woman with a fork in her neck who happens to be dying and has a struggling marriage. After a series of deaths at the hospital some of the staff become very superstitious.
Izzie worries about Denny and gets confronted by Alex. A patient with OCD drives Cristina crazy. Derek and Addison discuss their relationships with Meredith. Richard treats a friend from 17 years ago who reveals a secret about a dark time in his past that involves Ellis.
George gets an earful about the women he's not talking to. Burke and Cristina argue about kicking George out. Meredith and Izzie take up knitting. Derek operates on Andrew, a spelling bee champ with a serious head injury.
Bailey gets in on Andrew's surgery because she's worried that her coworkers won't recognize her Nazi-status now that she's a mother. Addison's patient has an unborn baby with medical issues. After Alex fails to bite his tongue when a terminal patient routinely lies to her daughter about her health he gets a lesson in bedside manners from Burke.
George also begins to overstay his welcome at Burke's apartment after Callie visits him. Meredith has more confusing and uncomfortable encounters with members of her family. One of the female doctors meets a veterinarian named Finn. Izzie flirts with Denny and they play more naughty-Scrabble. Meredith, Derek, and Addison sarcastically take another small stab at their friendships. Addison's patient is a Catholic mother of seven. Addison gets in trouble after learning that the patient's husband won't use contraceptives.
Derek treats a divorce attorney who asks if Derek is in need of her services. While Izzie and George are talking about their personal lives they "overhear" part of Derek's conversation with the divorce attorney who calls herself one of Seattle's best.
Alex gets in trouble with Addison yet again for not being able to keep his mouth shut when other people think he should. A legendary jazz musician refuses to see medical reason. The musician is Burke's musical hero. Finn makes Meredith breakfast. The staff attends to an intern from another hospital who has short-term memory loss. This intern, named Marshall, also has caused a car accident that involved a married couple, their unborn baby and the woman's parents who the staff are also treating.
The pregnant woman is named Melanie and she will die but her baby may survive. One of the female interns meets up with a woman from her past who is planning on having a family of her own. Cristina is in a good mood although Alex, Izzie, George, and Meredith are having problems but in the meantime Burke hasn't forgiven Cristina for her late night faux pas.
Meredith and Izzie are making fun of Callie's household habits and George and Callie are having a fight because of George's roommates.
Addison is continuing to own Alex and he's upset about it. Denny has an outburst at Izzie and Derek has an outburst at Meredith.
George and Derek work together, Denny still doesn't have a heart, and Meredith gets paired with Callie. A week pregnant girl dies in the O. This causes tension between Derek and Addison. One doctor's overreaction unites two bickering patients.
Finn is still treating Doc for medical problems. Denny needs a heart or else. Izzie and George go crazy trying to get him one. Derek has the life of a friend in his hands as he operates on Burke who has been shot.
Burke cannot operate on Denny after Denny's heart stopped and now Denny is in a dire condition. Cristina gets put in charge of the ER and she is worried about Burke. This episode is the second part of a two-hour season finale. Richard tries to get information from Addison about a family member's condition. Callie and George have a talk about his feelings.
Meredith and Derek have a talk about Doc. Meredith must make an important choice about which path she wants to follow to determine the future of her love life. While she considers her future she and others have flashbacks of their pasts. Cristina spends time with Burke while he recovers. Webber and Adele have a conversation after he spends the night at the hospital.
Everyone attempts to deal with Izzie's choice to quit. George seeks relationship advice from Derek. Cristina meets Burke's parents, the interns try to get Izzie's job back, and Addison takes a day off, a surgical patient may be living her last day. Some of the interns want to know why Bailey won't talk to Izzie. Meredith tries to decide between Derek and Finn and comes to a decision somewhat.
Webber finds out that Callie has been living in the hosiptal and he confronts her about it. The staff tries to prevent a patient from getting an elective surgery. Cristina tries to help Preston cope with the after effects of his surgery. A patient bails on their surgery. Someone goes to a bed-and breakfast. Alex deals with a patient who has had a high amount of injuries in the past.
A man undergoes surgery. Before the surgery his wife was only somewhat supportive, but the results may be too much for her to handle. Izzie tries to go back to the hospital for the first time since Denny died. One child's constant visits are noted by a nurse. Two foster patients are met with suspicions of child abuse. George and Callie's relationship moves forward. Shawn Sullivan, a car salesman who just had surgery, wants to get back to his routine so he doesn't lose his renown.
Addison works with a pregnant woman named Rebecca who may need a C-section and Addison doubts her medical skills. Rebecca wants to have the baby naturally. Derek and Mark's opinions clash when the try to decide the course of treatment for a burn victim. Izzie gets surprised. Cristina pushes Burke to get better faster.
Derek learns one of Addison's secrets. Bailey talks about motherhood and depression to a mother who is set to have cancer surgery and who seems to not care about any decisions concerning the future.
A resident is fiercely questioned about the death of a male patient. An ex-couple meet before lunch and get stuck - Meredith and Addison work on their case. Things get awkward when the ex-couple's daughter, Michelle, arrives at the hospital.
Cristina gets to scrub in on a rare surgery which incites envy. Alex questions his future in plastics. George and Addison work together with Noelle. Noelle is pregnant with twins but one of them is growing slower than the other. Derek's sister visits. A patient's wife makes things hard on the staff since she has made her husband's health her job.
A woman's sexual exploits are questioned. The men of Seattle Grace go on a camping trip together, Addison and Callie must team up to work on a patient, Meredith assists Sloan with a procedure unlike any she has experienced, and, suspicious of her recent actions at the hospital, Bailey confronts Cristina.
A 9-year-old is seen by Cristina after he swallowed Monopoly game pieces. A pregnant year-old, is brought in after she slipped in the shower. She doesn't want medicine to take away the pain from her injury so not to put her baby's growth in jeopardy. Doctors take care of Daniel, a man who wants a sexual reassignment surgery and who now goes under the name Donna. Accompanying Daniel is his wife of the past 10 years, who was surprised to see him want that surgery but, after much struggling, decided to stay by his side.
George's father has a serious heart problem that requires surgery and George chooses Burke to do the procedure. Burke doubts himself because he knows the pressure this kind of surgery will put on him, but Cristina believes the team can handle it. Derek works with Meredith on being a couple again and tries work with Addison on more civil terms. A patient has had mutiple plastic surgeries so that his girlfriend will like him more. A mom wants her daughter's babysitter fired, after she is brought in with multiple injuries, but the girl likes the babysitter more than her mother.
A traumatic car accident fills the ER. Izzie pushes the boundaries of her probation. Cristina has a crisis of conscience about her deceptive teamwork with Burke. Recent events strain Burke and Cristina's relationship.
Mark and Derek must work together when two close-knit brothers seek medical help. One of Meredith's half sisters is admitted to the hospital.
Meredith discovers that Derek has a problem sleeping while her father comes to visit the hospital. George's father is moving from one surgery to another. A patient named Heather checks into the hospital. Heather is 17 and has a nasty attitude that results from her medical condition and all the surgeries it has required her to have.
Izzie has an emotional breakdown when she tries to hand over something very important to her. George's family comes to visit to celebrate his father's surgery. Cristina and Burke are playing Uncle. Cristina and Burke continue to play Uncle until one of them gives in.
Derek and Meredith are fighting over the reason for their sleepless nights. Meredith tries to talk to her father about his side of the story. There's tension between Alex and Addison. There is even more tension between Addison and Mark. Addison confides in Callie. Bailey wishes she didn't have to keep a secret from one of the interns. Callie rushes to be with George after she learns that his dad needs an emergency procedure. Izzie may have found 'some good to do' with her inheritance.
After the Chief announces his retirement, rumors begin to circulate on his departure and successor. Mark is determined to leave Seattle for good but Meredith accidentally has him stay after letting him know of the open Chief position.
Derek is angry at Meredith for causing Mark to stay in Seattle, but soon realizes that she is not the reason he is really angry. The attending physicians at Seattle Grace Hospital fight to get Richard's attention, but he expresses his disappointment.
He also displays his lack of support in Bailey's plan to create a free medical clinic, but she ultimately goes through with her plan when Izzie offers to spend her entire 8.
George, devastated after his father's death, uses sex to overcome his grief, and eventually proposes to Callie. Cristina and Burke still don't speak to each other, but he breaks the agreement when he proposes to her. Richard endeavors to reunite with his wife, Adele, and decides to retire, only to come home and find his wife with another man. The race for the Chief's position is on, and the attending physicians, Derek, Burke, Addison and Mark, compete for Richard's affections by trying to help out everywhere possible.
The Denny Duquette Memorial Clinic is open for business, but only one single patient shows up. Izzie is disappointed in what she invested Denny's legacy in, and tries to steal patients from the emergency room. Callie and George get back from Las Vegas, announcing their marriage, much to everyone's disbelief. Izzie is not supportive of their marriage and tries to get George to realize the mistake he has made.
Meanwhile, Meredith's Alzheimer's-stricken mother, Ellis Grey, experiences a change in her medical condition by becoming lucid for the day. She is disappointed in the mediocrity her daughter has fallen into and begins to despise Derek, blaming him for what happened to the Meredith that used to be "a force of nature". Ellis has to have heart surgery and, despite her wishes, Meredith schedules her upcoming surgery. Richard talks to Ellis and realizes that she is still in love with him, but loses her memory after their talk ends, before Meredith has the chance to tell her how she really feels.
A mass trauma situation, which turns out to be a ferryboat accident, challenges the whole staff of Seattle Grace Hospital. Richard finds difficulty in coping with his separation from his wife and dyes his hair "for the ladies", which becomes an internal joke between Mark, Burke and Derek. Cristina tries to tell Meredith about her upcoming marriage, but doesn't have the strength to.
George promises to find a woman's son, who has been separated from her at the accident. The woman refuses to go into surgery until she is assured that her son is alive. Izzie has to take care of a man who got stuck between two cars on the ferry, but nobody helps her due to the large number of injured people.
Is there hope? On Grey's Anatomy Season 16 Episode 18, Meredith heads up a pro bono surgery day, but the overwhelming response causes her to struggle to keep things in order. On Grey's Anatomy Season 16 Episode 17, Meredith tries to save a woman who's been rationing her insulin. On Grey's Anatomy Season 16 Episode 16, while Meredith and several of the doctors reflect on the past. On Grey's Anatomy Season 16 Episode 15, Meredith and Carina question DeLuca's behavior when he volunteers to perform a life-threatening task during a blizzard.
On Grey's Anatomy Season 16 Episode 14, DeLuca is irritated after Meredith takes over his patient Suzanne whose symptoms continue to stump the doctors. On Grey's Anatomy Season 16 Episode 12, Jackson creates an uncomfortable situation when he invites his new girlfriend to a dinner that isn't what he expected. On Grey's Anatomy Season 16 Episode 9, Jo becomes a safe haven volunteer and gets a call that a baby is at Station 19 and Meredith moves forward with her life.
On Grey's Anatomy Season 16 Episode 8, Meredith faces the medical board and must reckon with her past in challenging ways while the interns are put to the test. On Grey's Anatomy Season 16 Episode 7, Owen and Amelia treat a woman who fell in the basement and realize that there is more to the story and Catherine returns. After Meredith inadvertently stirs up negative press for Grey Sloan, she tries to make things right with her former colleagues, jeopardizing her community service hours.
Station 19's Ben and Vic bring a young woman into the hospital, and Jackson stands up to Koracick when he goes too far with a patient's family. Meanwhile, Bailey receives unexpected news; and Owen finds himself at Pac-Gen North, which Alex sees as a recruiting opportunity.
S16, Ep5. Meredith has a court hearing after skipping out on community service, while Bailey and Jo have a patient that Jo realizes is from the treatment facility. Richard and Gemma grab breakfast together and things go awry. S16, Ep6. Alex is hoping to impress investors at Pac-Gen North, but when he hears disturbing news about skeletons on the construction site grounds, he enlists Richard to help with distraction tactics.
Teddy feels the pressure to be super-mom after tasking herself with creating original Halloween costumes for Allison and Leo, while Meredith fears she won't make it home in time for trick-or-treating with her kids. Elsewhere, Jackson tends to a pediatric patient who is upset she is spending her Halloween in a hospital. S16, Ep7. Catherine is back in town and has no idea what's been going on between Jackson and Maggie, while her relationship with Richard has become distant.
Owen and Amelia treat a woman who fell in the basement and quickly realize that there is more to the story; and Maggie is shocked to learn about some of Richard's relatives who are seeking help.
S16, Ep8. Meredith faces the medical board as her future as a doctor remains uncertain, and she's forced to reckon with her past in some challenging ways. Meanwhile, the interns are put to the test as they are each vying to be the most successful on their respective cases in the absence of some of the attendings. S16, Ep9. Jo becomes a safe haven volunteer and gets a call that a baby has been dropped off at Station Meanwhile, Meredith moves forward with her life after facing the medical board.
Jackson takes a big step in his budding romance with Vic, while Bailey and Amelia swap pregnancy updates. S16, Ep Following the car crash at Joe's Bar and subsequent rescue efforts led by the Station 19 firefighters, Grey Sloan doctors work through the night to save the lives of their colleagues. Meanwhile, Amelia worries about sharing her pregnancy revelation with Link.
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